Calf Muscles Imaged at BOLD MR: Correlation with TcPo2 and Flowmetry Measurements during Ischemia and Reactive Hyperemia—Initial Experience1
- Hans Peter Ledermann, MD,
- Hanns-Georg Heidecker, MD,
- Anja-Carina Schulte, PhD,
- Christoph Thalhammer, MD,
- Markus Aschwanden, MD,
- Kurt A. Jaeger, MD,
- Klaus Scheffler, PhD and
- Deniz Bilecen, MD, PhD
- 1From the Departments of Radiology (H.P.L., H.G.H., K.S., D.B.) and Angiology (C.T., M.A., K.A.J.), University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland; and MR- und Biocenter, University of Basel, Basel, Switzerland (A.C.S.). From the 2004 RSNA Annual Meeting. Received April 28, 2005; revision requested June 22; revision received September 13; accepted October 13; final version accepted March 1, 2006. Supported by the Swiss National Science Foundation Project-Nr: SNF: 3200B0-100359 and 3100A0-100633.
- Address correspondence to
D.B. (e-mail: dbilecen{at}uhbs.ch).
Abstract
Purpose: To prospectively compare the blood oxygen level–dependent (BOLD) magnetic resonance (MR) signal intensity of calf muscle during ischemia and reactive hyperemia with laser Doppler flowmetry (LDF) and transcutaneous oxygen pressure (TcPo2) measurements, two parameters routinely used to evaluate peripheral arterial occlusive disease.
Materials and Methods: The study was institutional review board approved; all volunteers gave informed consent. Fifteen healthy volunteers (eight male, seven female; mean age, 33.0 years ± 6.1 [standard deviation]) underwent LDF, TcPo2 measurement, and BOLD MR imaging of the calf during ischemia and reactive hyperemia. The BOLD signal intensity of the gastrocnemius muscle was measured at 1.5-T single-shot multiecho gradient-echo echo-planar imaging. Time to half ischemia minimum (THIM), time to half hyperemia peak (THHP), and time to peak (TTP) after cuff deflation were measured with each method. Correlation coefficients (CCs) for associations of BOLD response with LDF and TcPo2 time courses were calculated. Student t testing of key BOLD MR, LDF, and TcPo2 measurement parameters was performed.
Results: During ischemia, normalized LDF and TcPo2 measurements decreased similarly to BOLD MR signal intensity (CCs: 0.86 and 0.96 for associations with LDF and TcPo2 measurements, respectively). Mean THIM values were 136.0, 82.5, and 121.3 seconds for BOLD MR, LDF (P < .01), and TcPo2 (P > .05) measurements, respectively. During early reactive hyperemia, LDF and TcPo2 measurements increased rapidly to peak values, similarly to BOLD MR signal intensity (CCs: 0.81 and 0.78, respectively). Mean THHP values were 26.0, 12.5, and 44.0 seconds for BOLD MR, LDF (P < .01), and TcPo2 (P < .01) measurements, respectively. Mean TTP values were 48.7, 47.5, and 98.0 seconds for BOLD MR, LDF (P > .05), and TcPo2 (P < .01) measurements, respectively.
Conclusion: BOLD MR imaging of calf muscles—depending on underlying key parameters—has moderate to good correlation with LDF and TcPo2 measurements during ischemia and reactive hyperemia.
© RSNA, 2006
- BOLD = blood oxygen level dependent
- LDF = laser Doppler flowmetry
- PAOD = peripheral arterial occlusive disease
- TcPo2 = transcutaneous oxygen pressure
- THHP = time to half hyperemia peak
Footnotes
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Authors stated no financial relationship to disclose.
See also Science to Practice in this issue.
Author contributions: Guarantors of integrity of entire study, H.P.L., H.G.H., D.B.; study concepts/study design or data acquisition or data analysis/interpretation, all authors; manuscript drafting or manuscript revision for important intellectual content, all authors; manuscript final version approval, all authors; literature research, H.P.L., H.G.H., K.A.J., D.B.; clinical studies, H.P.L., H.G.H., A.C.S., C.T., M.A., K.A.J., D.B.; statistical analysis, H.G.H., A.C.S., D.B.; and manuscript editing, all authors
- © RSNA, 2006
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